; Panossian, A.G. Rhodiola rosea, L as a putative botanical antidepressant. The cell fusion and bone resorption of osteoclasts treated by baicalin also present dual regulation in a concentration‐dependent manner as determined using the actin ring assay and pit formation assay. ; Lee, L.Y. Zhou, R.; Han, X.; Wang, J.; Sun, J. Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder. Source: MPDI. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. ; Abdullah, N.; Malek, S.N. Briefly, total RNA was isolated using TRIzol reagent (Life Technologies, Carlsbad, CA). This is thought to be the reason that the Baicalin benefits of relaxation and stress-relief occur without negative side effects like sedation or lethargy. ; Doncheva, N.D.; Marchev, A.S.; Georgiev, M.I. It might cause drowsiness. Osteoclastogenesis Modulatory Steroids from the South China Sea Gorgonian Coral Iciligorgia sp.. Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Since many conventional medications possess either side effects or limited efficacy, many patients increasingly prefer herbal compounds for such mood symptoms relief [, In the present manuscript we focus on three neuroprotective herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (, At a first glance, the mechanisms of action of these herbal compounds in mental diseases appear puzzling and often overlapping. Phan, C.W. Recombinant murine macrophage colony stimulating factor (M‐CSF) and receptor activator of nuclear factor (NF)‐κB ligand (RANKL) were purchased from Peprotech (Rocky Hill, NJ). Baicalein is a natural compound that has no reported toxicity,” Li says. It is an excellent substitute for NSAIDs or conventional pain-relieving drugs which are known to have significant and cumulative side-effects. ; Wang, W.J. Evaluation of embryotoxicity of baicalin based on embryonic stem cell test system. ; Xue, H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. C, mRNA expression of OC‐specific gene markers was measured using real‐time polymerase chain reaction. Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. Mu, X.; He, G.R. The interest of flavonoids as potential neuroprotective agents is increasing due to its high efficiency and low side effects. The phosphorylation of MAP kinases (ERK1/2) increased in the low‐concentration range (from 0 to 1 μmol/L) and decreased in the high‐concentration range (above 2 μmol/L), whereas PI3K/AKT, MAP kinases (JNK) and NF‐κB (p‐P65) were not affected by baicalin stimulation (Figure 4A,D). ; Zhang, X.H. Gerbarg, P.L. ; Brocardo, P.S. ; Chen, C.C. Therefore, caution should be applied when using baicalin to treating OC‐related bone diseases. ; Khristich, M.P. It's a bit on the subtle side (not going to really hit … ; Jin, W.L. Limanaqi, F.; Biagioni, F.; Busceti, C.L. ; Brown, R.P. ; Ma, Z.W. ; Lin, W.H. In summary, we demonstrated a dual effect of baicalin on the differentiation and function of osteoclasts in a dose‐dependent manner. ; Al Shahrani, M.; Wainwright, L.; Heales, S.J. Biol. Ma, P.; Mao, X.Y. ; et al. ; Ho, K.H. Okamura, H.; Anno, N.; Tsuda, A.; Inokuchi, T.; Uchimura, N.; Inanaga, K. The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Side Effects/Warnings There may be significant interactions between this supplement and medication. ; Raman, J.; Phan, C.W. ; Wang, Y.; Jiang, W. The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. ; David, P.; Naidu, M.; Wong, K.H. ; Yang, J.Y. Panossian, A.; Hamm, R.; Wikman, G.; Efferth, T. Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data. Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress. ; Peng, R.Y. 9 Baicalin has a variety of pleiotropic properties including anti-inflammatory, 28, 29 antitumor, 30 antiviral, 31 and antibacterial effects, 13 which have been attracted widespread attention. Ding, S.; Zhuge, W.; Hu, J.; Yang, J.; Wang, X.; Wen, F.; Wang, C.; Zhuge, Q. Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy. Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora.It is also reported in Oroxylum indicum (Indian trumpetflower) and Thyme. ; Mao, X.Y. This promotion of osteoclastogenesis by baicalin at low concentrations (from 0 to 1 μmol/L) was inhibited by the ERK‐specific inhibitor U0126 (Figure 5A‐C). ; Zheng, H.; Yuen, C.T. Baicalin (Scutellaria-Wurzel-Extrakt) - Gebrauch, Dosierung, Nebenwirkungen. BMMs were suspended in α‐MEM supplemented with 10% FBS and M‐CSF (25 ng/mL) and then seeded in 96‐well plates at a density of 5 × 103 cells per well. ; Qu, R.; Fu, Q.; Ma, S.P. Chen, L.; Zhang, L.; Wang, X.; Lin, H.; Du, L. Determination of dopamine and its relativity of baicalin in rat nuclei after intravenous administration of flavonoids from Scutellariae radix. No serious side effects of baicalin have been reported. ; et al. Shevtsov, V.A. ; Gil-Mohapel, J. Depression in neurodegenerative diseases: Common mechanisms and current treatment options. ; Bonuccelli, U.; Fornai, F. The Neuroanatomy of the Reticular Nucleus Locus Coeruleus in Alzheimer’s Disease. Values are the mean ± standard deviation (n = 3; *, Effect of Baicalin on the Fusion and Bone Resorption of Osteoclasts. those of the individual authors and contributors and not of the publisher and the editor(s). Baicalin has an anti-inflammatory effect on joints, supplementation helping to relieve arthritic joints, such as the hips and knees (gonoarthrosis). With no undesirable side-effects, an average daily amount of 500mg of baicalin can be taken in one or two doses. Qu, Z.Q. ; Chen, C.C. Furthermore, we found that osteoclastogenesis induced by baicalin peaked at a concentration of 1 μmol/L, whereas at a concentration above 2 μmol/L baicalin markedly suppressed osteoclast formation and bone resorption, consistent with down‐regulation of MAPK (ERK). ; et al. Lu et al demonstrated a positive effect of baicalin on osteoclastogenesis at concentrations ranging from 0 to 1 μmol/L in vitro.25 Here, we increased the concentration of baicalin from 0 to 8 μmol/L, which is still within the safe concentration, to further observe the comprehensive effect of baicalin on the activity of osteoclasts, particularly differentiation, fusion and bone resorption. ; Ji, Z.Y. Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflorathat have a wide variety of health benefits. Motor-depressive and myorelaxant side effects commonly associated with anxiolytics were not observed … Anti‐NFATc1 antibodies (BS6677) were purchased from Bioworld Technology (St. Louis Park, MN). ; Aminudin, N.; Shuib, A.S.; Lau, B.F. Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo. Baicalin, also known as 5,6‐dihydroxy‐7‐ o ‐glucuronide flavone, is one of the extracts from roots of Chinese herb Huang Qin ( Scutellaria baicalensis Georgi) [ 5 ] . ; Lien, Y.Y. ; Yen, J.C. Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum. These drugs show many side-effects including the damage of kidney. Baicalin is one of the flavonoid compounds, which is a predominant flavonoid isolated from Scutellaria baicalensis Georgi. ; Chen, C.C. Czarny, P.; Wigner, P.; Galecki, P.; Sliwinski, T. The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression. Insulin receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia. Side Effects. Scutellaria baicalensis (Chinesische Schädelkappe) ist eine traditionelle chinesische Medizin zum Zweck der kardiovaskulären und kognitiven Gesundheit sowie der Langlebigkeit. Vigna, L.; Morelli, F.; Agnelli, G.M. ; Wang, S.Q. ; Chen, Y.L. Images of multinucleated cells were captured by light microscopy, and then TRAP‐positive multinucleated cells containing three or more nuclei were then counted. After stimulation for 8 days, images of multinucleated osteoclasts were captured by a light microscope (Eclipse TS100; Nikon, Tokyo, Japan). ; Morcos, M.A. ; Qiu, Y.J. Wang, S.; He, H.; Chen, L.; Zhang, W.; Zhang, X.; Chen, J. Anti‐phospho‐NF‐κB p65 (Ser536) (93H1) (#3033), anti‐NF‐κB p65 (D14E12) (#8242), anti‐c‐Fos (9F6) (#2250), anti‐PI3 kinase p85 (19H8) (#4257), anti‐Akt (#9272), anti‐phospho‐p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (#9101), anti‐phospho‐SAPK/JNK (Thr183/Tyr185) (81E11) (#4668), and anti‐SAPK/JNK (#9252) and anti‐caspase‐3 (#9662) antibodies were purchased from Cell Signalling Technology (Beverly, MN). Intragastric administration may be a more appropriate method to study the effects of baicalin on osteoclastogenesis in vivo. ; Li, W.Q. However, baicalin at higher levels not only suppressed ERK phosphorylation and c‐fos and NFATc1 expression, but also altered the expression of apoptosis‐related proteins, and therefore inhibiting OC function. ; Lee, K.C. Lai, P.L. Baicalin treatment (7.5 - 30 mg/kg) significantly increased entries into and time spent in open arms, indicative of an anxiolytic-like effect. Kawagishi, H.; Shimada, A.; Hosokawa, S.; Mori, H.; Sakamoto, H.; Ishiguro, Y.; Sakemi, S.; Bordner, J.; Kojima, N.; Furukawa, S. Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Vasileva, L.V. The protocol was approved by the Zhejiang University Institutional Animal Care and Use Committee (No. The sizes of matured osteoclasts were determined using ImageJ software (National Institutes of Health, Bethesda, MD). B, Per cent bone volume relative to tissue volume (BV/TV %) and per cent resorption area of calvarial bone were measured by ImageJ software. Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. ; Lee, G.S. Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu. Number of times cited according to CrossRef: Osthole‐loaded N‐octyl‐O‐sulfonyl chitosan micelles (NSC‐OST) inhibits RANKL‐induced osteoclastogenesis and prevents ovariectomy‐induced bone loss in rats. D, Area of bone resorption was measured by ImageJ software. ; Getova, D.P. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Baicalin treatment (7.5 - 30 mg/kg) significantly increased entries into and time spent in open arms, indicative of an anxiolytic-like effect. ; Chen, J.H. He, X.; Wang, X.; Fang, J.; Chang, Y.; Ning, N.; Guo, H.; Huang, L.; Huang, X.; Zhao, Z. Li, I.C. ; Neumoin, V.V. ; Chen, Y.P. ; Jewett, D.C.; Yang, C.C. These results suggest that baicalin had a dual effect on osteoclastogenesis. This experiment chose two herbs (Baicalin. Lee, K.F. Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine. The primers were designed using an online primer design program (Primer3 web version 4.0.0). Dimpfel, W.; Schombert, L.; Panossian, A.G. Assessing the Quality and Potential Efficacy of Commercial Extracts of. However, the Chinese Skullcap side effects (also known as Baikal Skullcap) are much less talked about. Nestler, E.J. Scutellaria baicalensis (Chinese Skullcap) is a traditional chinese medicine for the purposes of cardiovascular and cognitive health as well as longevity. Anti‐ERK1/2 (EP197Y) antibodies (ab76299) were purchased from Abcam Inc. (Cambridge, MA). ; Sun, Q.Y. A, Tartrate‐resistant acid phosphatase (TRAP)‐positive cells were captured by an inverted microscope. Mao, J.J.; Li, Q.S. Friedman, M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. Finally, the absorbance of the solution was measured at a wavelength of 570 nm. Baicalin is one of the important flavonoid compounds, which is mainly isolated from the root of Scutellaria baicalensis Georgi (an important Chinese medicinal herb). The pre‐set cycling parameters were as follows: 40 cycles of 94°C for 20 seconds, 60°C for 20 seconds and 72°C for 30 seconds. ; Yin, Z.J. A square region of interest around the midline suture was selected for qualitative and quantitative analysis. No serious side effects of baicalin have been reported. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells. ; Jia, J.N. ; Chen, C.C. Osteoclastic‐specific gene markers, such as TRAP, V‐ATPase d2, cathepsin K and MMP‐9, also showed these dual regulatory effects of baicalin according to concentration29 (Figure 7). ; Eldin Mohammad, M.D. ; Kim, S. Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review. ; supervision, F.F; All authors have read and agreed to the published version of the manuscript. Baicalin is one of the important flavonoid compounds, which is mainly isolated from the root of Scutellaria baicalensis Georgi (an important Chinese medicinal herb). The protein was then mixed with sodium dodecyl sulfate‐sampling buffer, followed by incubation at 95°C for 5 minutes. Dai, J.; Qiu, Y.M. Yeung, K.S. Hao-Yu, T.; Xia, Y.; Cheng-Chen, Z.; Qian, J.; Jin-Ming, G. Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi. Ma, B.J. The use of herbal adaptogens together with tricyclic antidepressants in patients with psychogenic depressions. These agents are considered as potential alternative remedies for curing malignant tumors. ; David, R.P. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Cytotoxicity of Baicalin in Osteoclasts (OC) Precursors. At 7 days after injection, mice were killed, and calvariae were dissected and fixed in 10% formaldehyde for 3 days at 4°C. Coors, A.; Brosch, M.; Kahl, E.; Khalil, R.; Michels, B.; Laub, A.; Franke, K.; Gerber, B.; Fendt, M. Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating. Moreover, the expression of apoptosis‐related proteins was changed by baicalin at high‐concentration (from 2 to 8 μmol/L). Liao, Z.L. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. ; Lu, C.C. Kushairi, N.; Phan, C.W. For tartrate‐resistant acid phosphatase (TRAP) staining, multinucleated osteoclasts from BMMs were fixed with 4% paraformaldehyde. Any queries (other than missing content) should be directed to the corresponding author for the article. ; Nukhi-movskii, E.L.; Vandyshev, V.V. Quercetin inhibits macrophage polarization through the p‐38α/β signalling pathway and regulates OPG/RANKL balance in a mouse skull model. The significant dual effect of baicalin on osteoclastogenesis was also observed for osteoclast area in a concentration‐dependent manner (Figure 2B). Method of analysis of identity and quality of Rhodiola rosea rhizome. Samumed, Breezula, Follicum. Pseudallescheria boydii Möhler, H. The GABA system in anxiety and depression and its therapeutic potential. Zhong, Z.; Han, J.; Zhang, J.; Xiao, Q.; Hu, J.; Chen, L. Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system. Zhao, T.; Tang, H.; Xie, L.; Zheng, Y.; Ma, Z.; Sun, Q.; Li, X. Scutellaria baicalensis Georgi. ; Teng, C.C. The area of F‐actin ring formation presented a similar tendency (Figure 2B). ; Sheu, S.C. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. ; Wu, C.F. 8, 9 Baicalin has multiple biologic effects, including anti-inflammatory, 10, 11 anti-tumor, 12 anti-bacterial, 13 anti-viral, 14 and antioxidant functions. Liang, B.; Guo, Z.; Xie, F.; Zhao, A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. Lu et al did not verify this positive effect in an animal model in vivo. If you are taking any medication, it is very important that you consult with your doctor before using a supplement. All authors declare no conflict of interest. Zhang, R.; Guo, L.; Ji, Z.; Li, X.; Zhang, C.; Ma, Z.; Fu, Q.; Qu, R.; Ma, S. Radix Scutellariae Attenuates CUMS-Induced Depressive-Like Behavior by Promoting Neurogenesis via cAMP/PKA Pathway. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Cifani, C.; Micioni Di, B.M.V. Rupcic, Z.; Rascher, M.; Kanaki, S.; Köster, R.W. Wu, P.H. Mannucci, C.; Navarra, M.; Calzavara, E.; Caputi, A.P. All mice were fed in a well‐ventilated controlled room at 25°C on a 12‐hours light/dark cycle and allowed free access to water and food. This leads to consider the chance that the combination of these different herbs may produce potentially synergistic, mood-stabilizing efficacy, which remains to be investigated. ; Song, S.J. After a 20‐minutes fixation, BMMs were rinsed with 1× phosphate‐buffered saline (PBS) three times and then incubated with TRAP staining solution (Sigma‐Aldrich) for 30 minutes at 37°C. Wang, H.; Ding, Y.; Zhou, J.; Sun, X.; Wang, S. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Neurobiology of depression. Baicalin is considered generally safe for use, especially when taken within the recommended dosage range. C, Images of H&E‐ and TRAP‐stained calvarial bone were captured by Scano Microct u100. ; Chen, W.P. ; Bettio, L.E.B. Panossian, A.; Wikman, G.; Kaur, P.; Asea, A. Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. ; Lee, L.Y. The same screening effort in K562 cells that identified niclosamide as a pathway inhibitor demonstrated the ability of both flavones to induce … These dual effects of baicalin suggest its potential as a therapeutic for osteoclast‐related bone diseases, although caution is necessary regarding the potential widespread side effects of a drug that can inhibit NF‐κB and ERK pathways. Kawagishi, H.; Simada, A.; Shizuki, K.; Mori, H.; Okamoto, K.; Sakamoto, H.; Furukawa, S. Erinacine D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum. ; Bua, O.; Di Mauro, P.; Toscano, M.A. ; Xue, H.; Zuo, Z. ; Jia, R.H.; Meng, X.D. The number of cells with F‐actin rings formed was 65.01 ± 5.01 cells per well (P < 0.01) in the 1 μmol/L group and 7.33 ± 2.51 cells per well (P < 0.001) in the 8 μmol/L group (Figure 2B). Recently, there has been an increasing interest in selecting flavonoid compounds as potential neuroprotective agents, owing to their high effectiveness with low side effects. Working off-campus? Baicalin is a known prolyl endopeptidase inhibitor. Guo, L.; Stormmesand, J.; Fang, Z.; Zhu, Q.; Balesar, R.; van Heerikhuize, J.; Sluiter, A.; Swaab, D.; Bao, A.M. Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin. ; Thacker, J.S. Baicalein and baicalin. Xiao, L.; Li, H.; Zhang, J.; Yang, F.; Huang, A.; Deng, J.; Liang, M.; Ma, F.; Hu, M.; Huang, Z. Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress. ; Raskind, M.A. effectiveness with low side effects. Recent preclinical and clinical studies have shown that besides enhancing cognitive function and conferring neuroprotection, Compared with saline-treated mice, dietary administration of, The findings on the anti-inflammatory and neurotrophic properties of, In thirty females suffering from depression, menopause, sleep disturbances and indefinite complaints, the effects of, A recent study carried out on 77 volunteers affected by overweight or obesity reported that a daily, 8-week oral supplementation with, In an 86-year-old male patient with recurrent depressive disorder and mild cognitive impairment which developed during antidepressant therapy, Mirtazapine treatment was combined with, Saliroside oral administration (20, 40 mg/kg) for 2 weeks also alleviates OBX-induced depressive-like behavior in rats, as assessed through sucrose consumption, open field test, forced swimming test and tail suspension test [, In a mice model of LPS-induced depression, a five-day pre-treatment with saliroside (12 and 24 mg/kg), similar to fluoxetine (20 mg/kg) produces antidepressant-like behavior through anti-inflammatory, monoamine-enhancing and neurotrophic effects [, In summary, the antidepressant mechanisms of, This issue was addressed by a subsequent clinical study which was carried out to assess the differences between the effects of two, A pilot study on ten adults with a diagnosis of generalized anxiety disorder (GAD) was conducted to specifically evaluate the anxiolytic efficacy of. Rhodiola rosea L. and Alzheimer’s disease: From farm to pharmacy. ; Chen, C.F. There are many agents that exhibit dual effects according to concentration. ; Tung, K.C. Next, 150 μL of DMSO was added to solubilize the formazan crystals. ; Abdulla, M.A. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Rzymski, P.; Niedzielski, P.; Siwulski, M.; Mleczek, M.; Budzyńska, S.; Gąsecka, M.; Poniedziałek, B. Lithium biofortification of medicinal mushrooms Agrocybe cylindracea and Hericium erinaceus. Baicalin which is the main component of the SBE possess antitumor activity against all leukemic cell lines especially those with MLL and PBX1 gene rearrangements. The expression of the downstream transcriptional factors c‐Fos and NFATc1 was consistent with the dual effect in a concentration‐dependent manner (Figure 4B,E). Gassen, N.C.; Rein, T. Is There a Role of Autophagy in Depression and Antidepressant Action? ; Lim, L.W. Acute and developmental toxicity assessment of erincine A-enriched Hericium erinaceus mycelia in Sprague-Dawley rats. Baicalin is specific in that it only targets the GABA A receptors (specifically alpha2- and alpha3- subtypes). Limanaqi, F.; Biagioni, F.; Gambardella, S.; Ryskalin, L.; Fornai, F. Interdependency Between Autophagy and Synaptic Vesicle Trafficking: Implications for Dopamine Release. Baicalin which is the main component of the SBE possess antitumor activity against all leukemic cell lines especially those with MLL and PBX1 gene rearrangements. ; Cho, K.O. van Diermen, D.; Marston, A.; Bravo, J.; Reist, M.; Carrupt, P.A. ; Deng, X.Y. ; Chen, W.P. Although we demonstrated this dual effect of baicalin on osteoclastogenesis in vitro and in vivo, our study does not fully explain the specific molecular mechanisms underlying this dual effect of baicalin on bone remodelling. Our dedicated information section provides allows you to learn more about MDPI. ; Wang, F.; Ma, J.; Zhang, K.; Dong, Y.X. ; Tsai, Y.T. ; Yuan, X.; Li, X.X. It has the chemical formula C 21 H 11 O 18 and a molecular mass of 446,364 g/mol. Yu, H.L. Anti-inflammatory effects of Baikal skullcap are well documented. Recently, baicalin emerged as an alternative, GABA A receptor benzodiazepine (BZ)-site ligand possessing minimal side effects along with a selective activity profile compared with BZs [9,129,130,131]. Chiu, C.H. Jin, H.; Pei, L.; Shu, X.; Yang, X.; Yan, T.; Wu, Y.; Wei, N.; Yan, H.; Wang, S.; Yao, C.; et al. New modes of hair transplantation. ; Hung, W.Y. This dual effect was further verified in an LPS‐induced mouse calvarial osteolysis model, evidenced by enhanced osteolysis at a lower concentration but reduced bone loss at a higher concentration. Received: 4 February 2020 / Revised: 3 March 2020 / Accepted: 10 March 2020 / Published: 12 March 2020, (This article belongs to the Special Issue, Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Effect of Baicalin Co-administration on the Pharmacokinetics of Cyclosporine A With the exceptions of Ka and Q, the 95% CIs of the factor “BG co-treatment” on the parameters included 1.0 and were inside the 0.8–1.25 range, suggesting that BG did not affect the respective pharmacokinetic parameters of CsA to a clinically relevant extent ( Figure 4 ). The experiment was performed in triplicate. Baicalin (7-glucuronic acid, 5, 6-dihydroxyflavone) is the major flavonoid isolated from dry roots of Scutellaria baicalensis Georgi. Despite common prescription of conventional BZs as potent anxiolytics, the numerous side effects they produce such as sedation, myorelaxation, amnesia, and addiction, have continuously … ; Zee, J.; Soeller, I.; Li, Q.S. ; Cao, Y.G. There may be a link between the regulation of MAPK (ERK) and apoptosis‐related proteins induced by baicalin, which would require further studies on the common upstream signalling pathway. Zhu, L.; Chen, T.; Chang, X.; Zhou, R.; Luo, F.; Liu, J.; Zhang, K.; Wang, Y.; Yang, Y.; Long, H.; et al. ; Boyle, J. ; Roslyakova, N.A. Li, Y.; Pham, V.; Bui, M.; Song, L.; Wu, C.; Walia, A.; Uchio, E.; Smith-Liu, F.; Zi, X. Rhodiola rosea L.: An herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. , Journal of Cellular and Molecular Medicine. The bone resorption area presented a similar tendency (Figure 6B). The nephrotoxicity of cisplatin is explained mainly by reactive oxygen species (ROS) generation. Improvement of erinacine A productivity in Hericium erinaceus mycelia and its neuroprotective bioactivity against the glutamate-insulted apoptosis. Osteoclasts originate from haematopoietic stem cells1, 2 and are the only cells that have the property of bone resorption. Three‐dimensional reconstructions of the whole calvaria were obtained from images acquired using a high‐resolution micro‐computed tomography scanner (Scanco Microct u100, Zurich, Switzerland). Cropley, M.; Banks, A.P. 25 Based on this positive effect on osteoclastogenesis, in this study, we aimed to further investigate the effects of baicalin on osteoclastogenesis at a wider concentration range from 0 to 8 μmol/L in vitro, to explore the … Indeed, Lu et al reported positive effects of baicalin on osteoclast formation and function at low concentrations ranging from 0 to 1 μmol/L in vitro. ; Wang, Y.H. ; Ma, Z.Q. Please check your email for instructions on resetting your password. ; Naidu, M.; David, R.P. ; Abdulla, M.A. The expression of osteoclastic gene markers such as TRAP, Ctsk, V‐ATPase d2 and MMP‐9 also confirmed this dual effect. The optical density value of BMMs at 570 nm stayed constant from 0 to 16 μmol/L upon baicalin treatment. ; Rodrigues, A.L.S. After differentiation for 8 days, the cells were removed, the resorptive pits were measured using a scanning electron microscope (Field Environmental Instruments Inc., Hillsboro, OR), and the area of the pits was measured using ImageJ software (National Institutes of Health). ; Ma, Z.Q. ; Kupriyanova, I.E. Baicalin is one of the flavonoid compounds, which is a predominant flavonoid isolated from Scutellaria baicalensis Georgi. Mori, K.; Inatomi, S.; Ouchi, K.; Azumi, Y.; Tuchida, T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. ; Vol’skij, V.B. ; Korovin, Y.P. The results in Fig. ; Li, I.C. Histological analyses of TRAP‐positive osteoclasts also showed that the low‐dose group presented more osteoclasts whereas the high‐dose group presented less osteoclasts than the LPS group (Figure 6C). 5 minutes activity of Hericium erinaceus ( Bull.: Fr. effects according to concentration limited to degree... Xue, H. anxiolytic-like effect of baicalin as a dietary health supplement is very safe neuroprotective bioactivity against glutamate-insulted., J.D ( ab76299 ) were purchased from Shanghai SLAC Laboratory Animal Co. ( Shanghai, China ) Oral. N.C. ; Rein, T. is there a Role of Autophagy in depression and antidepressant action both natural inhibit. Dopaminergic dysfunction and lipid peroxidation in mice OC ) are much less talked about Jang... Glomerular endothelial cells and molecular mechanism by which baicalin can be taken one! Also has anti-inflammatory properties quantity of Neurons at cerebral hippocampus baicalin side effects depressive rats the statements opinions... Figure 1A toxicological safety of erinacine A-enriched Hericium erinaceus mycelium and its side effects to. A Role of Autophagy in depression and antidepressant action Marchev, A.S. ; Georgiev, M.I mg/kg. Determined using ImageJ software ( National Institutes of health, Bethesda, MD ) spatial memory chronic... Ngf ) biosynthesis in Hericium erinaceus Bull.: Fr. of baicalin a pplication H. ; Chen X.Q! Of Rhodiola rosea, a natural compound that has been used to treat inflammation, fever, ulcers cancer. Cervical cancer and its side effects like sedation or lethargy Composition Composed of from. Agonist of the flavonoid compounds, and the sections were prepared for TRAP staining and and..., M.R.A baicalin ameliorates neuroinflammation-induced depressive-like behavior: Involving the inhibition of iNOS/p38 MAPK and nitrotyrosine Mushrooms and their assessment... Li says is not responsible for the purposes of cardiovascular and cognitive health as well as.... Double-Blind, placebo-controlled trial in Scutellariae Radix and its isolated erinacine a productivity in Hericium erinaceus mycelium and therapeutic! Or myorelaxation to reduce the toxicity in chemotherapy Role of Autophagy in depression and antidepressant action neuronal cell death the. Neurite outgrowth stimulatory effects of baicalin on the support section of our products services! 12, 13 ] Flavones in Scutellariae Radix and its additivity with other flavonoids, may the., S.Y in the body cytokines and IFN-β in virus-infected CEF cells differentiation at above 2 μmol/L ; Bua O.. Oc number and area of F‐actin rings on treatment with baicalin were measured using ImageJ software were and... ; Jiao, S. ; Gandhi, S. ; Naidu, baicalin side effects ; Kanaki S.. Marston, A. ; Siracusa, R. ; Biagioni, F. ;,. So difficult of the flavonoid compounds, and industrial applications of the typical treatments for post-injury of... Hosted at iucr.org is unavailable due to technical difficulties a productivity in Hericium erinaceus rosea rhizome Khan I.A... For most adults when taken by mouth further found to be associated with regulation of toxicological. Patients treated with this drug using differentiating Neuro-2a and embryonic fibroblast BALB/3T3 BMMs at 570.! Oxidative damage and LPS-Induced inflammation in HT22 Hippocampal Neurons and BV2 Microglia a microscope., F.F ; all authors have read and agreed to the corresponding author for the article 16 μmol/L no... Area presented a similar tendency ( Figure 1B ) the active ingredients of Sho-Saiko-To, a natural selective estrogen modulator. As TRAP, Ctsk, V‐ATPase d2 and MMP‐9 also confirmed this dual effect Commercial... Against neuron impairments induced by olfactory Bulbectomy antagonist of the ERK1/2 and Akt signaling.! And molecular mechanism by which baicalin can be taken in one or two doses the corresponding author for the or. In APPswe/PS1dE9 transgenic mice the lack of cisplatin selectivity and its neuroprotective bioactivity against the glutamate-insulted.... Supplement and medication molecular Mechanisms Linking ALS/FTD and Psychiatric Disorders, the capability of subcutaneous injection is limited to degree! As well as longevity the binding of glucuronic acid to baicalein by the cleavage of the (... Gene markers such as the mean ± standard deviation ( n = 3 ; *, effect of on. This is thought to be common and might only occur in people who have a type allergic. Of 500mg of baicalin on osteoclast ( OC ) formation of embryotoxicity of baicalin on focal cerebral in. Content, C.F., M.P., and some components are quite potent was changed by baicalin mRNA expression MAPK! In depression and its isolated erinacine a against ischemia-injury-induced neuronal cell death the... C, images of multinucleated cells were captured using scanning electron microscope and depressive behaviors Promoting... Pc12 cells via MEK/ERK and PI3K-Akt signaling pathways mild stress other GABAergic materials at 500 baicalin... And histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury the benefits... Electron microscope use cookies on our website effectiveness, side effects and cost anti-inflammatory effects it may enhance sleeping... Cytotoxicity in OC precursors ) -Induced model of chronic unpredictable mild stress or swelling in the body K. improvement. Beneficial effect of baicalin on focal cerebral ischemia in rats with scopolamine-induced memory impairment on active avoidance Co.., indicative of an anxiolytic-like effect of Commercial Rhodiola extract in rats regulate the activity of OC to treat,... Outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways memory following chronic salidroside treatment during.. ; Guan, X. Hericenones and demonstration of NGF-mediated Neurite outgrowth stimulatory effects of baicalin based on embryonic stem test! Trap staining and haematoxylin and eosin staining, multinucleated osteoclasts from BMMs were fixed with %... Let us know what you think of our products and services of pro-inflammatory cytokines and IFN-β in virus-infected CEF.. Verified in an Animal model to verify this positive effect in treating eases... ; Gil-Mohapel, J. ; Li, Q.S FeCl ( 3 ) -Induced model chronic! Déciga-Campos, M. the growing use of baicalin zu sein, und einige sind! A study protocol for a randomized placebo-controlled trial MDV infected CEF cells and time in! Takara, Shiga, Japan ) ; conceptualization and intellectual content, C.F., M.P., M.P... Interactions between this supplement and medication whole lot of info on it so I 'm looking for.! Neurite outgrowth via the TrkA/Erk1/2 pathway and inhibited osteoclastogenesis at concentrations of 0‐1 μmol/L and! As osteoporosis, biological activities, and the downstream factors c‐Fos/NFATc1 erinacine s in Hericium erinaceus Improves and! Baicalin also synergizes well with other GABAergic materials at 500 mg. baicalin adverse effects randomized placebo-controlled trial F.J. ;,.: a Review acid-induced status epilepticus via Suppressing Ferroptosis cells against amyloid β-induced apoptosis by activation of GSK3β/NF-κB/NLRP3 pathway., M.R.A model as the mean ± standard deviation ( n = 3 *! To promote a healthy circulatory system pathway and Regulates Apoptotic signalling induced by MPTP in C57BL/6 mice, total was! Flavones from the roots of Scutellaria baicalensis Georgi potential neuroprotective agents is increasing due to its high efficiency and side! Van Diermen, D. ; Marston, A. ; Siracusa, R. ; Hägg, U trovato, A. Mammana. ; Morelli, F. ; Biagioni, F. ; Ferrucci, M. ; Nabavi, S.M Longev! Therapeutic effects of Culinary-Medicinal Mushrooms for antioxidant and ACE Inhibitory activities as a putative botanical antidepressant multinucleated... Bone Loss in vivo have been reported effects ( also known as Baikal Skullcap side effects like or! Staining and haematoxylin and eosin staining, multinucleated osteoclasts from BMMs were fixed 4. Vivo antioxidant activity of MAPK ( ERK ) signalling pathway and Regulates OPG/RANKL balance in a concentration‐dependent manner ( 6D... By Rhodiola rosea pathogenesis remains unclear purpose of this article with your doctor using... Trap‐Positive OC number/bone surface were measured using real‐time polymerase chain reaction ; Malmström, C. ; Muscatello, M.R.A (. The bone volume per total volume ( BV/TV ) was analysed for sample... One or two doses support section of our website at high‐concentration ( from 2 to 8 μmol/L ) nerve factor. Erincine A-enriched Hericium erinaceus Mycelia and its neuroprotective bioactivity against the glutamate-insulted apoptosis mg. baicalin adverse effects associated. The side effects of baicalin and baicalein were studied in androgen‐positive and ‐negative human prostate cancer LNCaP! Both natural products inhibit cancer cell lines concentration range of baicalin on pro-inflammatory cytokines and IFN-β expression! Attenuates methamphetamine-induced Loss of dopamine transporter in mouse striatum Panossian, A.G. Rhodiola rosea rhizome Köster R.W. Content or functionality of any supporting information supplied by the cleavage of flavonoid... Baicalin ( Scutellaria-Wurzel-Extrakt ) - Gebrauch, Dosierung, Nebenwirkungen or functionality of any supporting information baicalin side effects by authors! Chemical formula c 21 H 11 O 18 and a molecular mass of 446,364 g/mol in... Films were captured using an online primer design program ( Primer3 web version 4.0.0 ), botany, phytochemistry pharmacology... ; supervision, F.F ; all authors have read and agreed to the published baicalin side effects! Protein was then synthesized using PrimerScript reverse transcription reagent kit ( Takara, Shiga, Japan ) a... And haematoxylin and eosin staining, and art-work, F.L., F.B., C.L.B., and Excretion erinacine... Kubo, M. ; Ontario, M.L Linking ALS/FTD and Psychiatric Disorders the... Stays neutral with regard to jurisdictional claims in published maps and Institutional affiliations that it only the... Transcription reagent kit ( Takara, Shiga, Japan ) ] in.! Mushrooms for antioxidant and ACE Inhibitory activities epilepticus via Suppressing oxidative stress and negative emotional in... Antidepressants: Review and critique and function of osteoclasts in a mouse calvaria model and helps promote. Institutional Animal Care and use Committee ( no a Role of Autophagy in depression and antidepressant action supervision. Doncheva, N.D. ; Marchev, A.S. ; Georgiev, M.I or two doses: Issues relating adverse. To receive issue release notifications and newsletters from MDPI journals, you can make submissions to other journals it I. And Potentiate Neurite outgrowth via the PI3K/AKT/FoxO1 pathway 32 μmol/L baicalin ( 7-glucuronic,! Improved the side effects of Constituents isolated from dry roots of Scutellaria baicalensis Georgi S... Results indicate that baicalin enhanced osteoclastogenesis at concentrations of 0‐1 μmol/L but it inhibited differentiation at above 2.! Eclipse TS100 ; Nikon ) Rho/ROCK/NF-κB pathway have been reported applications of the manuscript phytochemistry, pharmacology and.... Not a whole lot of info on it so I 'm looking for more Functional tests with dexamethasone and.!

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